|
KMID : 0360419940300030299
|
|
Korean Journal of Pharmacology
1994 Volume.30 No. 3 p.299 ~ p.311
|
|
|
The Mode of Action of Pentazocine on Catecholamine Secretion from the Perfused Rat Adrenal Medulla
|
|
Lim Dong-Yoon
Kim Bong-Han
Heo Jae-Bong
Choi Chul-Hee
Kim Jin-Ho
Jang Young
Lee Jae-Joon
|
|
|
Abstract
|
|
|
|
The present study was attempted to investigate whether pentazocine, which is known to possess both opioid agonistic and antagonistic properties, produces catecholamines (CA) secretion from the isolated perfused rat adrenal gland, and to establish the mechanism of its action, and also to compare its action with that of some opioids. Pentazocine (30 to 300 ug) injected into an adrenal vein caused a dose-dependent secretory response of CA from the rat adrenal medulla. The pentazocine-evoked secretion of CA was remarkably diminished by the preloading with chlorisondamine , naloxone , morphine , met-enkephalin , nicardipine and TMB-8 while was not influenced by the pretreatment of pirenzepine . The perfusion of -free Krebs solution for 30 min into the gland also led to the marked reduction in CA secretion evoked by pentazocine. Furthermore, the CA release evoked by ACh and/or DMPP was greatly inhibited by the pretreatment with pentazocine for 20 min. From these experimental results, it is thought that pentazocine causes markedly the increased secretion of CA from the isolated perfused rat adrenal medulla by a calcium-dependent exocytotic mechanism. The secretory effect of pentazocine appears to be mediated through activation of opioid receptors located on adrenal chromaffin cells, which may be also associated with stimulation of cholinergic nicotinic receptors.
|
|
|
KEYWORD
|
|
|
Pentazocine, Catecholamine secretion, Opiate receptors, Adrenal gland
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|